{"id":25,"date":"2016-02-03T14:30:17","date_gmt":"2016-02-03T14:30:17","guid":{"rendered":"http:\/\/centroceci.com.ar\/web\/?page_id=25"},"modified":"2024-11-22T16:53:55","modified_gmt":"2024-11-22T16:53:55","slug":"investigaciones-clinicas","status":"publish","type":"page","link":"http:\/\/centroceci.com.ar\/web\/investigaciones-clinicas\/","title":{"rendered":"Investigaci\u00f3n"},"content":{"rendered":"

En el\u00a0Centro de Estudios en Cardiolog\u00eda Intervencionista<\/em>\u00a0(CECI) somos un grupo independiente de investigadores cl\u00ednicos entrenados para brindar soluciones integrales para la realizaci\u00f3n de Investigaci\u00f3n Cl\u00ednica de fase IIIb y IV.<\/p>\n

Como\u00a0Contract Research Organization\u00a0<\/strong>(CRO), en el CECI contamos con una gran experiencia en el campo de la cardiolog\u00eda. Desde hace 25 a\u00f1os venimos capacit\u00e1ndonos y perfeccion\u00e1ndonos para brindar un servicio completo, desde el dise\u00f1o del protocolo, organizaci\u00f3n y coordinanci\u00f3n log\u00edsitica, management, evaluaci\u00f3n de centros, an\u00e1lisis estad\u00edsitico, redacci\u00f3n de manuscritos y presentaci\u00f3n en congresos y revistas arbitriradas. Como un grupo boutique sabemos que nuestra fuerza es mantener la independencia y la veracidad de los datos para lograr un an\u00e1lisis correcto de la informaci\u00f3n m\u00e9dica que se desprende de ellos. Para ello trabajamos con pasi\u00f3n y profesionalismo.<\/p>\n

# El Fenomeno de early Recoil y el proceso de Reestenosis post balon.<\/p>\n

En los a\u00f1os\u00a01993, 1995 se describi\u00f3 por primera vez a un subgrupo de pacientes que se pod\u00eda detectar precozmente\u00a0post angioplastia con balon,POBA, cuales tienen alta posibilidad de hacer reestenosis coronaria temprana debido al fen\u00f3meno de retracci\u00f3n el\u00e1stica de la pared del vaso que se denomin\u00f3\u00a0early recoil.<\/em><\/p>\n

Estos trabajos observacionales algunos, y randomizados otros se publicaron en el Am J Cardiol 1993 y 1995; Circulation en 1995 y en el JACC 1998.<\/p>\n

Fueron referencia obligada durante la d\u00e9cada\u00a0de los 90 y utilizado para justificar el uso del stent met\u00e1lico para prevenir este recoil el\u00e1stico.<\/p>\n

De hecho uno de estos trabajos publicado en Circulation y realizado por el grupo CECI y el Dr Alfredo Rodriguez en Argentina,\u00a0Coronary stenting decreases restenosis in lesions with early loss in luminal diameter 24 hours after successful PTCA. Circulation 1995;91:1397\u2013402,<\/em>fue una de las referencias usadas por la compa\u00f1\u00eda\u00a0que fabricaba el stent de Gianturco Roubin II, Cook Inc, para lograr que la FDA de USA aprobar\u00e1 que el stent de Gianturco-Roubin sea el primer stent bal\u00f3n- expandible aprobado en USA para su uso cl\u00ednico un a\u00f1o\u00a0antes que el stent de Palmaz-Schatz.<\/p>\n

Ac\u00e1 est\u00e1n\u00a0las referencias incluyendo las de Gary Roubin quien fue el inventor del stent Gianturco-Roubin.<\/p>\n

#\u00a0Rodr\u0131guez A, Santaera O, Larribau M, Sosa MI, Palacios IF. Early decrease in minimal luminal diameter after successful percutaneous transluminal coronary angioplasty predicts late restenosis. Am J Cardiol 1993;71:1391\u20135<\/p>\n

#\u00a0Rodr\u0131guez A, Palacios I, Ferna\u00b4ndez M, Larribau M, Giraudo M, Ambrose J. Time course and mechanism of early luminal diameter loss after percutaneous transluminal coronary angioplasty. Am J Cardiol 1995;76:1131\u20134. 9.<\/p>\n

# Rodr\u0131guez A, Santaera O, Larribau M, et al. Coronary stenting decreases restenosis in lesions with early loss in luminal diameter 24 hours after successful PTCA. Circulation 1995;91:1397\u2013402.<\/p>\n

#\u00a0Rodriguez\u00a0 A\u00a0, Ayala F, Bernardi V et al\u00a0\u00a0Optimal coronary balloon angioplasty with provisional stenting versus primary stent (OCBAS): immediate and long-term follow-up results J Am Coll Cardiol.\u00a01998 Nov;32(5):1351-7\u00a0\u00a0—<\/p>\n

#\u00a0 Roubin GS, Cannon AD, Agrawal SK, et al. Intracoronary stenting for acute and threatened closure complicating percutaneous transluminal coronary angioplasty.Circulation. 1992;85:916\u2013927<\/p>\n

#\u00a0 The First Balloon-Expandable Coronary Stent: An expedition that Changed Cardiovascular Medicine. Roubin, Gary: University of Queensland Press 2014. (Amazon.com).<\/p>\n

# Roubin Gary S\u00a0 The coronary stent: the rocket engine that launched contemporary cardiac and vascular intervention.<\/p>\n

# Revista Argentina de Cardioangiolog\u00eda Intervencionista 2023;14(4):156-159. https:\/\/doi.org\/10.30567\/RACI\/202304\/0156-0159<\/a><\/h4>\n

<\/div>\n
<\/div>\n

<\/h2>\n

Algunos de los estudios que dise\u00f1amos, organizamos, analizamos y realizamos el manuscrito final, actuando como CRO de punta a punta.<\/strong><\/h4>\n

ERACI I<\/strong><\/p>\n

Argentine randomized\u00a0trial<\/strong>\u00a0of percutaneous transluminal coronary angioplasty versus coronary artery bypass surgery in multivessel disease (ERACI<\/strong>): in-hospital results and 1-year follow-up.ERACI<\/strong>\u00a0Group.<\/u>J Am Coll Cardiol. 1993 Oct;22(4):1060-7.<\/p>\n

Three-year follow-up of the Argentine Randomized\u00a0Trial<\/strong>\u00a0of Percutaneous Transluminal Coronary Angioplasty Versus Coronary Artery Bypass Surgery in Multivessel Disease (ERACI<\/strong>).<\/a>J Am Coll Cardiol. 1996 Apr;27(5):1178-84<\/p>\n

ERACI II<\/strong><\/p>\n

Coronary stenting versus coronary bypass surgery in patients with multiple vessel disease and significant proximal LAD stenosis: results from the\u00a0ERACI<\/strong>\u00a0II study.<\/a>\u00a0Heart. 2003 Feb;89(2):184-8.<\/p>\n

Five-year follow-up of the Argentine randomized\u00a0trial<\/strong>\u00a0of coronary angioplasty with stenting versus coronary bypass surgery in patients with multiple vessel disease (ERACI<\/strong>\u00a0II).<\/a>\u00a0J Am Coll Cardiol. 2005 Aug 16;46(4):582-8.<\/p>\n

ERACI III<\/strong><\/p>\n

Coronary stent thrombosis in the current drug-eluting stent era: insights from the\u00a0ERACI<\/strong>\u00a0III\u00a0trial<\/strong>.<\/a>\u00a0J Am Coll Cardiol. 2006 Jan 3;47(1):205-7.<\/p>\n

Revascularization strategies of coronary multiple vessel disease in the Drug Eluting Stent Era: one year follow-up results of the\u00a0ERACI<\/strong>\u00a0III\u00a0Trial<\/strong>.<\/a>\u00a0EuroIntervention. 2006 May;2(1):53-60.<\/p>\n

Late loss of early benefit from drug-eluting stents when compared with bare-metal stents and coronary artery bypass surgery: 3 years follow-up of the\u00a0ERACI<\/strong>\u00a0III registry.<\/a>\u00a0Eur Heart J. 2007 Sep;28(17):2118-25<\/p>\n

Long-term safety and efficacy of percutaneous coronary intervention with stenting and coronary artery bypass surgery for multivessel coronary artery disease: a meta-analysis with 5-year patient-level data from the ARTS,\u00a0ERACI<\/strong>-II, MASS-II, and SoS\u00a0trials<\/strong>.<\/a>\u00a0Circulation. 2008 Sep 9;118(11):1146-54<\/p>\n

Percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass surgery for multivessel coronary artery disease: a meta-analysis of data from the ARTS II, CARDia,\u00a0ERACI<\/strong>III, and SYNTAX studies and systematic review of observational data.<\/a>\u00a0EuroIntervention. 2010 Jun;6(2):269-76<\/p>\n

ERACI IV<\/strong><\/p>\n

Second versus first generation DES in multiple vessel disease and unprotected left main stenosis: insights from\u00a0ERACI<\/strong>\u00a0IV Study.<\/a> Minerva Cardioangiol. 2015 Aug;63(4):317-27<\/p>\n

Modifying angiographic syntax score according to PCI strategy: lessons learnt from\u00a0ERACI<\/strong>\u00a0IV Study<\/a> Cardiovasc Revasc Med. 2015 Oct-Nov;16(7):418-20.<\/p>\n

Second vs. First Generation Drug Eluting Stents in Multiple Vessel Disease and Left Main Stenosis: Two-Year Follow-Up of the Observational, Prospective, Controlled and Multicenter ERACI IV Registry.\u00bb Accepted article ahead of-print.<\/p>\n

ORAR I<\/strong><\/p>\n

Pilot study of oral rapamycin to prevent restenosis in patients undergoing coronary stent therapy: Argentina Single-Center Study (ORAR<\/strong>\u00a0Trial<\/strong>).<\/a>\u00a0J Invasive Cardiol. 2003 Oct;15(10):581-4.<\/p>\n

Role of oral rapamycin to prevent restenosis in patients with de novo lesions undergoing coronary stenting: results of the Argentina single centre study (ORAR<\/strong>\u00a0trial<\/strong>).<\/a>\u00a0Heart. 2005 Nov;91(11):1433-7<\/p>\n

ORAR II<\/strong><\/p>\n

Oral rapamycin after coronary bare-metal stent implantation to prevent restenosis: the Prospective, Randomized Oral Rapamycin in Argentina (ORAR<\/strong>\u00a0II) Study.<\/a>\u00a0J Am Coll Cardiol. 2006 Apr 18;47(8):1522-9<\/p>\n

ORAR III<\/strong><\/p>\n

Percutaneous coronary intervention with oral sirolimus and bare metal stents has comparable safety and efficacy to treatment with drug eluting stents, but with significant cost saving: long-term follow-up results from the randomised, controlled\u00a0ORAR<\/strong>\u00a0III (Oral Rapamycin in ARgentina) study.<\/a>\u00a0EuroIntervention. 2009 Jun;5(2):255-64.<\/p>\n

Randomized comparison of cost-saving and effectiveness of oral rapamycin plus bare-metal stents with drug-eluting stents: three-year outcome from the randomized oral rapamycin in Argentina (ORAR<\/strong>) III\u00a0trial<\/strong>.<\/a>\u00a0Catheter Cardiovasc Interv. 2012 Sep 1;80(3):385-94<\/p>\n

Comparison of cost-effectiveness of oral rapamycin plus bare-metal stents versus first generation of drug-eluting stents (from the Randomized Oral Rapamycin in Argentina [ORAR<\/strong>] 3\u00a0trial<\/strong>).<\/a>\u00a0Am J Cardiol. 2014 Mar 1;113(5):815-21.<\/p>\n

GRAMI TRIAL<\/strong><\/p>\n

In-hospital and late results of coronary stents versus conventional balloon angioplasty in acute myocardial infarction (GRAMI<\/strong>\u00a0trial<\/strong>). Gianturco-Roubin in Acute Myocardial Infarction.<\/a>Am J Cardiol. 1998 Jun 1;81(11):1286-91.<\/p>\n

OCBAS TRIAL<\/strong><\/p>\n

Optimal coronary balloon angioplasty with provisional stenting versus primary stent (OCBAS<\/strong>): immediate and long-term follow-up results.<\/a>\u00a0J Am Coll Cardiol. 1998 Nov;32(5):1351-7.<\/p>\n

The role of acute wall recoil and late restenosis: results of the\u00a0OCBAS<\/strong>\u00a0trial<\/strong>\u00a0(Optimal Coronary Balloon Angioplasty with Provisional Stenting versus Primary Stent).<\/a>\u00a0Int J Cardiovasc Intervent. 2001 Jun;4(2):99-106<\/p>\n

LASMAL I<\/strong><\/p>\n

Latin American randomized trial of balloon angioplasty vs coronary stenting for small vessels (LASMAL<\/strong>): immediate and long-term results.<\/a>\u00a0Am J Med. 2005 Jul;118(7):743-51.<\/p>\n

LASMAL II<\/strong><\/p>\n

Latin American randomized trial of balloon angioplasty versus coronary stenting in diabetic patients with small vessel reference size (Latin American Small Vessel [LASMAL<\/strong>\u00a0II] Trial): immediate and long-term results.<\/a>\u00a0Am Heart J. 2005 Jul;150(1):188.<\/p>\n

EUCATAX<\/strong><\/p>\n

Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: the\u00a0EUCATAX<\/strong>\u00a0trial<\/strong>.<\/a>\u00a0Catheter Cardiovasc Interv. 2011 Feb 15;77(3):335-42<\/p>\n

CAMOUFLAGE<\/strong><\/p>\n

New coating stent design for patients with high-risk coronary lesions for thrombotic events: early and long-term results of the\u00a0Camouflage<\/strong>\u00a0registry<\/strong>.<\/a>\u00a0J Invasive Cardiol. 2009 Aug;21(8):378-82.<\/p>\n

DEAR<\/strong><\/p>\n

One-year outcome of patients with diabetes mellitus after percutaneous coronary intervention with three different revascularization strategies: results from the Diabetic Argentina\u00a0Registry<\/strong>\u00a0(DEAR<\/strong>).<\/a>\u00a0Cardiovasc Revasc Med. 2012 Sep-Oct;13(5):265-71.<\/p>\n

La extensa experiencia en la conducci\u00f3n de estudios cl\u00ednicos tanto a nivel nacional como internacional permite a los clientes tener acceso a importantes expertos alrededor del mundo y al\u00a0CECI\u00a0brindar las mejores opciones costo efectivas para lograr los objetivos propuestos.<\/p>\n","protected":false},"excerpt":{"rendered":"

En el\u00a0Centro de Estudios en Cardiolog\u00eda Intervencionista\u00a0(CECI) somos un grupo independiente de investigadores cl\u00ednicos entrenados para brindar soluciones integrales para la realizaci\u00f3n de Investigaci\u00f3n Cl\u00ednica de fase IIIb y IV. Como\u00a0Contract Research Organization\u00a0(CRO), en el CECI contamos con una gran experiencia en el campo de la cardiolog\u00eda. Desde hace 25 a\u00f1os venimos capacit\u00e1ndonos y perfeccion\u00e1ndonos …<\/p>\n","protected":false},"author":1,"featured_media":26,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":[],"_links":{"self":[{"href":"http:\/\/centroceci.com.ar\/web\/wp-json\/wp\/v2\/pages\/25"}],"collection":[{"href":"http:\/\/centroceci.com.ar\/web\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/centroceci.com.ar\/web\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/centroceci.com.ar\/web\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/centroceci.com.ar\/web\/wp-json\/wp\/v2\/comments?post=25"}],"version-history":[{"count":10,"href":"http:\/\/centroceci.com.ar\/web\/wp-json\/wp\/v2\/pages\/25\/revisions"}],"predecessor-version":[{"id":711,"href":"http:\/\/centroceci.com.ar\/web\/wp-json\/wp\/v2\/pages\/25\/revisions\/711"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/centroceci.com.ar\/web\/wp-json\/wp\/v2\/media\/26"}],"wp:attachment":[{"href":"http:\/\/centroceci.com.ar\/web\/wp-json\/wp\/v2\/media?parent=25"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}